Principal Advisor: Associate Professor Dominic Ng

Email: d.ng1@uq.edu.au

Phone: 07 3365 3077

Research group page: Ng Group - Kinase biology

Organisational unit: School of Biomedical Sciences

Primary cilium are non-motile, microtubule-based sensory appendages found on most cells. Once thought to be vestigial organelles, it is now evident that cilia interact with the extracellular environment and co-ordinate cell proliferation, differentiation and cell-cell communication. Defects in cilia formation or function underlie a broad spectrum of clinical conditions collectively known as ciliopathies, reinforcing important roles for cilia in human health. This project will delineate poorly understood contributions of primary cilium in the growth and repair of striated muscle. We will explore intrinsic functions of cilia on muscle progenitors regulating a transition between proliferation and commitment to muscle formation (myogenesis). We will also explore potential interactions between cilia and the extracellular matrix microenvironment and how this may influence muscle aging and repair in response to injury or disease.