Principal Advisor: Professor Di Yu


Research group: Yu Group - T-cell immune mechanism, monitoring and modulation

Organisational unit: UQ Diamantina Institute

Cytotoxic CD8+ T (Tc) cells constitute the major immune cell type that is responsible for eliminating infected or cancerous cells. Tc cells differentiate into specialised subsets that localise to specific tissues and organs to perform their cell killing functions but may also mediate immunopathology. Professor Di Yu's laboratory pioneers in discovering new T cell subsets and unveiling mechanisms underlying their differentiation and function. This project will utilise both pre-clinical animal models and bioinformatic approaches to characterise novel Tc subsets, including ‘follicular cytotoxic T cells’ (Tfc cells). The gained new knowledge will help to design new strategies to treat cancers and infectious diseases such as caused by HIV, EBV and SARS-CoV-2. A PhD scholarship is available for this project.