Principal Advisor: Dr Snehlata Kumari

Email: s.kumari@uq.edu.au

Research group: Kumari Group - Immuno-modulatory signalling

Organisational unit: UQ Diamantina Institute

Our work is focused on elucidating immuno-modulatory signalling mechanisms regulating inflammation to develop new therapeutic strategies for inflammatory skin diseases and cancer. The skin forms immunological, mechanical and structural barriers to protect the organisms from external challenges. Active communication between soluble factors and cells in the skin, such as epithelia, stromal and immune cells are crucial to maintain skin homeostasis. We have previously shown that NF-kappaB, cytokine and cell death signalling pathways are crucial in regulating inflammation. We aim to deciphering novel signalling pathways and mechanisms in immune and non-immune cells in regulating skin inflammation and cancer. The project provides excellent exciting opportunity to students to learn and engage in techniques in Immunology, Molecular Biology, Cell Biology and Genetics including microscopy, CRISPR/Cas9-mediated genetic engineering, flow cytometry as well as in vitro and in vivo models.