Principal Advisor: Professor Colleen Lau or Dr Luis Furuya-Kanamori

Email: colleen.lau@uq.edu.au

Organisational unit: School of Public Health, School of Clinical Medicine

Rabies is an invariably fatal viral zoonosis in humans. Current Australian guidelines for people who work with bats (e.g. bat handlers, veterinarians) is to receive rabies pre-exposure prophylaxis (PrEP) comprising of three intramuscular vaccines on days 0, 7, and 21-28. People with ongoing occupational exposure to rabies virus (and other lyssaviruses) are recommended to have antibody titres measures every 6-24 months, and if the titres fall below 0.5 IU/mL it is recommended to receive a booster dose. Using longitudinal data from a cohort of bat handlers, the aims of the project are i) to identify the ideal time after the primary vaccination for antibody titre measurements, and ii) to explore the effect of receiving multiple booster doses over time.