Principal Advisor: Dr Antiopi Varelias

Email: antiopi.varelias@qimrberghofer.edu.au

Phone: 07 3362 0322

Research group: Transplantation immunology

Organisational unit: QIMR Berghofer, School of Clinical Medicine

Viral infection following stem cell transplantation (SCT) is a common complication following this procedure which is performed for the treatment of blood cancers. One such pathogen is respiratory syncytial virus (RSV), a common infection that leads to significant mortality in these immunocompromised patients. Current treatment strategies using anti-viral agents are ineffective and thus this complication remains a significant clinical problem where new treatments are urgently needed. To address this, a better understanding of the immunological mechanisms which underlie this complication are vital. Thus, the aim of this research project is to elucidate the cellular and molecular mechanisms that control Pneumonia Virus of Mice (the murine relative of human RSV) which governs increased mortality after transplant. This project is not limited to, but will involve, extensive animal work, flow cytometry, immunological assays, molecular and viral techniques.