Molecular regulation of innate immune receptor functions in infection and inflammation
Principal Advisor: Professor Antje Blumenthal
Email: a.blumenthal@uq.edu.au
Organisational unit: Frazer Institute
The ability to detect, integrate and respond to signals from the environment and within tissues is crucial for the survival of all organisms. Innate immune receptors are proteins pivotal in sensing microbes including potentially harmful pathogens, and are key initiators of inflammation and antimicrobial defence. Whereas these immune mechanisms are essential for host control of pathogens, they pose significant risks if unchecked, leading to organ damage and chronic disease. This project will drive new discoveries how innate immune receptors function in the initiation of inflammation and antimicrobial defence, and how these mechanisms are regulated to protect the host. Our long-term goal is to use this knowledge to develop targeted interventions for improved outcomes in infectious and inflammatory diseases. This project will enable you to develop in-depth knowledge of innate immunity and molecular and cellular mechanisms that underpin inflammation and antimicrobial defence. You will build a portfolio of skills in cutting-edge techniques in cellular and molecular immunology, molecular imaging, and biochemistry. In addition to discipline knowledge, transferable skills developed and encouraged include project planning and management, data analysis and interpretation, presentations at project meetings and conferences to expert and non-expert audiences, effective communication within and across teams, time management and prioritisation, scientific writing and publishing of research findings, contributions to the organisation.